Proliferation of T lymphocytes is triggered by the interaction of IL-2 with its specific receptor
following T lymphocyte activation. The receptor for IL-2 consists of at least three distinct …

Rapamycin has potent immunosuppressive properties reflecting its ability to disrupt cytokine
signaling that promotes lymphocyte growth and differentiation. In IL-2-stimulated T cells …

The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events
mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane …

Publisher Summary This chapter provides an overview of receptor activation from
biochemical and cellular studies regarding immune system development and function when …

Cytokines represent a diverse group of molecules that transmit intercellular signals. These
signals may either be autocrine (where the same cell both produces the cytokine and …

Publisher Summary This chapter focuses on two sets of molecules involved in the
proliferation and differentiation of highly purified human B lymphocytes: the molecules …

The high‐affinity receptors for granulocyte‐macrophage colony stimulating factor (GM‐CSF),
interleukin 3 (IL‐3) and IL‐5 consist of two subunits, alpha and beta. The alpha subunits are …

Publisher Summary This chapter focuses on the origins, structure, and role of the janus
protein tyrosine kinase in cytokine signaling and attempts to integrate the rapidly emerging …

To elucidate the physiological role of human stromelysin-3 (hST-3) in tumor progression
and/or wound healing, insulin-like growth factor-binding protein-1 (IGFBP-1) was analyzed …

Abstract p85/p110 phosphoinositide 3‐kinase (PI3K) is a heterodimer composed of a p85‐
regulatory and a p110‐catalytic subunit, which is involved in a variety of cellular responses …