Learning Objective: After participating in this activity, learners should be better able to:
Evaluate the rationale for and current evidence supporting medication-assisted treatment of …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

G protein-coupled receptors (GPCRs) can initiate intracellular signaling cascades by
coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins …

Identifying neurons that have functional opioid receptors is fundamental for the
understanding of the cellular, synaptic and systems actions of opioids. Current techniques …

Several non-caloric sweeteners exhibit a delay in sweetness onset and a sweetness linger
after sampling. These temporal properties are thought to be the result of non-specific …

Opioid receptors are G protein-coupled receptors (GPCRs) that regulate activity within
peripheral, subcortical and cortical circuits involved in pain, reward, and aversion …

The atypical chemokine receptor ACKR3 contributes to chemotaxis by binding, internalizing,
and degrading the chemokines CXCL11 and CXCL12 to shape and terminate chemotactic …

Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor
(MOR) and the associated physiological effects is critical for the development of novel …

The ventral pallidum (VP) is a target of dense nucleus accumbens projections. Many of
these projections coexpress GABA and the neuropeptide enkephalin, a δ and μ opioid …

A major function of GPCRs is to inhibit presynaptic neurotransmitter release, requiring ligand-
activated receptors to couple locally to effectors at terminals. The current understanding of …