Regulation of reproduction via tight control of gonadotropin hormone levels

D Coss - Molecular and cellular endocrinology, 2018 - Elsevier
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …

Minireview: activin signaling in gonadotropes: what does the FOX say… to the SMAD?

J Fortin, L Ongaro, Y Li, S Tran, P Lamba… - Molecular …, 2015 - academic.oup.com
The activins were discovered and named based on their abilities to stimulate FSH secretion
and FSHβ (Fshb) subunit expression by pituitary gonadotrope cells. According to …

Pituitary transcriptomic study reveals the differential regulation of lncRNAs and mRNAs related to prolificacy in different FecB genotyping sheep

J Zheng, Z Wang, H Yang, X Yao, P Yang, CF Ren… - Genes, 2019 - mdpi.com
Long non-coding RNA (LncRNA) have been identified as important regulators in the
hypothalamic-pituitary-ovarian axis associated with sheep prolificacy. However, their …

Growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) are potential intraovarian regulators of steroidogenesis in Japanese flounder …

H Yu, Y Wang, M Wang, Y Liu, J Cheng… - General and Comparative …, 2020 - Elsevier
Members of transforming growth factor-β (TGF-β) superfamily are vital regulators during the
development of fish ovary. However, its intraovarian functions in teleost are still unclear. As …

Inactivation of growth differentiation factor 9 blocks folliculogenesis in pigs

PR Chen, K Uh, K Monarch, LD Spate… - Biology of …, 2023 - academic.oup.com
Abstract Growth differentiation factor 9 (GDF9) is a secreted protein belonging to the
transforming growth factor beta superfamily and has been well characterized for its role …

[HTML][HTML] Mathematical modeling of gonadotropin-releasing hormone signaling

A Pratap, KL Garner, M Voliotis… - Molecular and cellular …, 2017 - Elsevier
Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary
gonadotropes to control reproduction. These are G q-coupled receptors that mediate acute …

Expression Patterns and Gonadotropin Regulation of the TGF-β II Receptor (Bmpr2) during Ovarian Development in the Ricefield Eel Monopterus albus

Z He, L Zheng, Q Chen, S Xiong, Z He, J Hu… - International Journal of …, 2022 - mdpi.com
Bmpr2 plays a central role in the regulation of reproductive development in mammals, but its
role during ovarian development in fish is still unclear. To ascertain the function of bmpr2 in …

Clinical applications of gonadotropins in the male

A Ulloa-Aguirre, S Lira-Albarrán - Progress in molecular biology and …, 2016 - Elsevier
The pituitary gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone
(FSH) play a pivotal role in reproduction. The synthesis and secretion of gonadotropins are …

Goat CLSTN2 gene: tissue expression profile, genetic variation, and its associations with litter size

D Wijayanti, Y Bai, Q Hanif, H Chen, H Zhu… - Animal …, 2023 - Taylor & Francis
Abstract Calsyntenin-2 (CLSTN2) is involved in cell proliferation, differentiation, cell death,
tumorigenesis, and follicular expression. Although CLSTN2 has been identified as a …

Detection of polymorphisms in six genes and their association analysis with litter size in sheep

K Liu, Y Liu, M Chu - Animal Biotechnology, 2024 - Taylor & Francis
Litter size in sheep is a complex trait controlled by micro-effective polygenes. APAF1,
CLSTN2, CTH, PLCB1, PLCB4, and CHST11 are all involved in mammalian reproduction …