Unraveling the big sleep: molecular aspects of stem cell dormancy and hibernation

IB Dias, HR Bouma, RH Henning - Frontiers in Physiology, 2021 - frontiersin.org
Tissue-resident stem cells may enter a dormant state, also known as quiescence, which
allows them to withstand metabolic stress and unfavorable conditions. Similarly, hibernating …

Amelioration of muscle wasting by glucagon‐like peptide‐1 receptor agonist in muscle atrophy

Y Hong, JH Lee, KW Jeong, CS Choi… - Journal of cachexia …, 2019 - Wiley Online Library
Background Skeletal muscle atrophy is defined as a reduction of muscle mass caused by
excessive protein degradation. However, the development of therapeutic interventions is still …

Suspended in time: molecular responses to hibernation also promote longevity

R Al-Attar, KB Storey - Experimental Gerontology, 2020 - Elsevier
Aging in most animals is an inevitable process that causes or is a result of physiological,
biochemical, and molecular changes in the body, and has a strong influence on an …

Oyster hydrolysates attenuate muscle atrophy via regulating protein turnover and mitochondria biogenesis in C2C12 cell and immobilized mice

SH Jeon, SY Choung - Nutrients, 2021 - mdpi.com
Sarcopenia, also known as skeletal muscle atrophy, is characterized by significant loss of
muscle mass and strength. Oyster (Crassostrea gigas) hydrolysates have anti-cancer …

Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels

Y Yang, Z Hao, N An, Y Han, W Miao… - Journal of Cellular …, 2023 - Wiley Online Library
Hibernating mammals are natural models of resistance to ischemia, hypoxia‐reperfusion
injury, and hypothermia. Daurian ground squirrels (spermophilus dauricus) can adapt to …

Soluble whey protein hydrolysate ameliorates muscle atrophy induced by immobilization via regulating the PI3K/Akt pathway in C57BL/6 mice

JE Shin, SJ Park, SI Ahn, SY Choung - Nutrients, 2020 - mdpi.com
Sarcopenia, a loss of skeletal muscle mass and function, is prevalent in older people and
associated with functional decline and mortality. Protein supplementation is necessary to …

Codonopsis lanceolata and its active component Tangshenoside I ameliorate skeletal muscle atrophy via regulating the PI3K/Akt and SIRT1/PGC-1α pathways

TY Kim, KT Park, SY Choung - Phytomedicine, 2022 - Elsevier
Background: Skeletal muscle atrophy is caused by aging, disuse, malnutrition, and several
diseases. However, there are still no effective drugs or treatments for muscle atrophy …

MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

BE Luu, E Lefai, S Giroud, JE Swenson… - Journal of Cellular …, 2020 - Wiley Online Library
Hibernating brown bears, Ursus arctos, undergo extended periods of inactivity and yet these
large hibernators are resilient to muscle disuse atrophy. Physiological characteristics …

[HTML][HTML] Jakyak-gamcho-tang, a decoction of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma, ameliorates dexamethasone-induced muscle atrophy and muscle …

A Kim, YR Kim, SM Park, H Lee, M Park, JM Yi, S Cha… - Phytomedicine, 2024 - Elsevier
Background Although chronic treatment with glucocorticoids, such as dexamethasone, is
frequently associated with muscle atrophy, effective and safe therapeutics for treating …

Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps

A Capraro, D O'Meally, SA Waters, HR Patel… - BMC genomics, 2019 - Springer
Background Hibernation is a physiological state exploited by many animals exposed to
prolonged adverse environmental conditions associated with winter. Large changes in …