Endothelial and vascular smooth muscle dysfunction in hypertension

MG de Oliveira, W Nadruz Jr, FZ Monica - Biochemical pharmacology, 2022 - Elsevier
The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

L-NAME in the cardiovascular system—nitric oxide synthase activator?

J Kopincová, A Púzserová, I Bernátová - Pharmacological Reports, 2012 - Springer
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both
in vitro and in vivo, with N ω-nitro-L-arginine methyl ester (L-NAME) being at the head. On …

Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum

H Zhang, WT Tong, CR Zhang, JL Li… - … syndrome and obesity …, 2019 - Taylor & Francis
Objective To investigate the effect of gross saponins of Tribulus terrestris (GSTT) on erectile
function in rats resulting from type 2 diabetes mellitus (T2DMED). Methods The T2DMED …

[HTML][HTML] Gas what: NO is not the only answer to sexual function

G Yetik-Anacak, R Sorrentino, AE Linder… - British journal of …, 2015 - ncbi.nlm.nih.gov
The ability to get and keep an erection is important to men for several reasons and the
inability is known as erectile dysfunction (ED). ED has started to be accepted as an early …

Oral l‐Citrulline Supplementation Improves Erectile Function in Rats with Acute Arteriogenic Erectile Dysfunction

A Shiota, Y Hotta, T Kataoka, M Morita… - The journal of sexual …, 2013 - academic.oup.com
Introduction Oral l‐citrulline supplementation increases serum l‐arginine levels more
efficiently than l‐arginine itself and increases nitric oxide (NO) production. Aim To …

PDE5 inhibitors: targeting erectile dysfunction in diabetics

SH Francis, JD Corbin - Current opinion in pharmacology, 2011 - Elsevier
Erectile dysfunction (ED) is strongly linked to cardiovascular disease (CVD), especially in
diabetics. ED is associated with deleterious changes in the overall vasculature and is …

Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension

P Chiangsaen, P Maneesai, U Kukongviriyapan… - Reproductive …, 2020 - Elsevier
Tangeretin is a polymethoxyflavone concentrated in citrus peels and has several biological
activities. This study examined whether tangeretin improved reproductive dysfunction in N ω …

Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies

DS Sá, AF Fernandes, CDS Silva, PPC Costa… - Dalton …, 2015 - pubs.rsc.org
There is an increasing number of compounds developed to target one or more pathways
involved in vasodilation. Some studies conducted with azaindole and indazole derivatives …

Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat.

B Rocha, AR Rodrigues, I Tomada, MJ Martins… - Nutrition & …, 2018 - Springer
Background Endothelial dysfunction underlies cardiovascular disease that frequently affects
aged individuals. Characterized by local decrease in nitric oxide, it results from down …

Comparison of enhanced male mice sexual function among three medicinal materials

S Gu, R Zhou, X Wang - Andrologia, 2018 - Wiley Online Library
To compare the effect of Epimedium brevicornum Maxim., Cynomorium songaricum Rupr.
and Morindae officinalis FC How on enhancing sexual function effect, mice were …