Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform
to allow degradation of intracellular components, including soluble proteins, aggregated …

There are inherent limitations with traditional methods to study protein behavior or to
determine the constituency of proteins in discrete subcellular compartments. In response to …

The single gene, single protein, single function hypothesis is increasingly becoming
obsolete. Numerous studies have demonstrated that individual proteins can moonlight …

Autophagy is a process delivering cytoplasmic components to lysosomes for degradation.
Autophagy may, however, play a role in unconventional secretion of leaderless cytosolic …