Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …

Prevention, accurate diagnosis, and effective treatment of infections are the main challenges
in the overall management of infectious diseases. The best example is the ongoing SARs …

Indole and its derivatives are well-known assorted motif in drug design and development.
We here in reporting synthesis of new 9-chloro-1-(4-substituted phenyl)-12H-indolo [2, 3 …

Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …

In the present study, a combination of theoretical and experimental methods has been
employed to evaluate and understand the molecular geometrical properties of 1-(4 …

Spiro-compounds are a significant class of naturally occurring materials distinguished by
their prominent biological characteristics. Spiro [indole-thiazolidines] analogues find an …

In recent years, viral infections such as COVID-19, Zika virus, Nipah virus, Ebola, Influenza,
Monkeypox, and Dengue have substantially impacted global health. These outbreaks have …

Around 1.6 million people lost their life to Tuberculosis in 2021 according to WHO estimates.
Although an intensive treatment plan exists against the causal agent, Mycobacterium …

A series of new spirothiazolidinone derivatives with a mandelic acid moiety were
synthesized and subsequently tested in growth inhibition assays against Mycobacterium …

Indole, a fundamental heterocyclic core, has emerged as a cornerstone in the medicinal
chemistry due to its diverse biological activities and structural versatility. This aromatic …