The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing
tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet …

Tyrosinase (EC 1.14. 18.1), a copper‐containing enzyme, can cause enzymatic browning in
raw fruits, vegetables, and beverages. Browning is an undesirable reaction that is …

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

Melanin, a major pigment in mammalian skin, is known to protect the skin against harmful
effects of ultraviolet (UV) irradiation, oxidative stress, and DNA damage. The accumulation …

To find new potential tyrosinase inhibitors, a diverse range of 2-arylchromone-4-thione
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …

Azoles are a famous and promising class of drugs for treatment of a range of ailments
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …

The fruit of Dillenia indica L. is extensively used as a food additive. Betulinic acid (BA) is the
most prominent secondary metabolite present in D. indica. This study screened the bioassay …

Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has
become an extremely important target for inhibition in several sectors of research including …

Highlights•The effective usage of food colorant apocarotenoids as an alternative to synthetic
anti-browning agent.•Apocarotenoids reversibly inhibited tyrosinase activity through …