Hydrolases are well-known for hydrolyzing esters, amides, carbamates, peptides, or acid
anhydrides in the presence of water. However, some of them are also capable of catalyzing …

Thermostability enhancement is a fundamental aspect of protein engineering as a
biocatalyst's half-life is key for its industrial and biotechnological application, particularly at …

Simvastatin is a top-selling cholesterol-lowering drug traditionally obtained through a semi-
synthetic process starting from lovastatin. However, this process is cost-demanding and …

This study identifies new acyl donors for manufacturing statin analogues through the
acylation of monacolin J acid by the laboratory evolved acyltransferase LovD9. Vinyl and p …

Recombinant proteins and antibodies are routinely used as drugs to treat prevalent
diseases such as diabetes or cancer, while enzyme replacement and gene therapies are the …

This work presents Neural Optimization for Melting-temperature Enabled by Leveraging
Translation (NOMELT), a novel approach for designing and ranking high-temperature stable …

This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. As part of directed evolution of stereoselective enzymes in …

Abstract Machine learning and deep learning are revolutionizing protein science by
enabling the prediction of complex, emergent biophysical properties. This thesis presents …

Deep learning has found its way into the chemical sciences, and brought with it successes
that have been observed in “traditional” applications such as computer vision and sentiment …