The marine environment represents an outstanding source of antitumoral compounds and,
at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide …

Proteasomes play a critical role in the fate of proteins that are involved in major cellular
processes, including signal transduction, gene expression, cell cycle, replication …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by a rapid
increase in the number of immature myeloid cells in bone marrow. Despite recent advances …

Pemetrexed (ALIMTA, Lilly) is a folate antimetabolite that has been approved by the US
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …

The multigenic nature of human tumours presents a fundamental challenge for cancer drug
discovery. Here we use Drosophila to generate 32 multigenic models of colon cancer using …

Interactions between the Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 and the
proteasome inhibitor (bortezomib) were examined in diffuse large‐B cell lymphoma …

Introduction The use of nanoparticles for breast cancer targeting and treatment has become
a reality. They are safe and possess interesting peculiarities such as the unspecific …

The incidence of melanoma has increased rapidly over the past few decades, with mortality
accounting for more than 75% of all skin cancers. The high metastatic potential of Melanoma …

The cell cycle-related genes AURKA and FOXM1 are overexpressed in melanoma. We
show here that AURKA overexpression is associated with poor prognosis in three …

Abstract Control of BRAF (V600E) metastatic melanoma by BRAF inhibitor (BRAF-I) is
limited by intrinsic and acquired resistance. Growth factor receptor up-regulation is among …