Rheumatoid arthritis (RA) is a chronic inflammatory synovitis that is dominated by the
presence of macrophages, lymphocytes and synovial fibroblasts, which leads to the …

Rheumatoid arthritis (RA) is a chronic inflammatory disease, which results in inflammation of
the synovial lining and destruction of the adjacent bone and cartilage. Synovial …

Galectin-1 (GAL-1), a member of a family of conserved β-galactoside–binding proteins, has
been shown to induce in vitro apoptosis of activated T cells and immature thymocytes. We …

Objective To investigate the impact of a prolonged and constant active TGF-β expression by
the synovial lining cells on cartilage and ligamentous joint structures in vivo. Design An …

The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis of
tumor cells but not normal cells; its role in normal nontransformed tissues is unknown. We …

Various cancer cell lines express Fas ligand (FasL) and can kill lymphoid cells by Fas-
mediated apoptosis in vitro. FasL expression has been demonstrated in several human …

Apoptotic cell death mediated by the members of the tumor necrosis factor receptor family is
an essential process involved in the regulation of cellular homeostasis during development …

DNA origami is capable of spatially organizing molecules into sophisticated geometric
patterns with nanometric precision. Here we describe a reconfigurable, two-dimensional …

The predominance of autoimmune diseases among women suggests that estrogen may
modulate immune function. Monocytes and macrophages are important in initiating …

TRAIL, the TNF-related apoptosis-inducing ligand, induces apoptosis of tumor cells, but not
normal cells; the roles of TRAIL in nontransformed tissues are unknown. Using a soluble …