Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Sexual transmission of Zika virus and other flaviviruses: a living systematic review

MJ Counotte, CR Kim, J Wang, K Bernstein… - PLoS …, 2018 - journals.plos.org
Background Health authorities in the United States and Europe reported an increasing
number of travel-associated episodes of sexual transmission of Zika virus (ZIKV) following …

Effect of Spirulina platensis on growth, hematological, biochemical, and immunological parameters of Nile tilapia (Oreochromis niloticus)

IMI Youssef, ESE Saleh, SS Tawfeek… - Tropical Animal Health …, 2023 - Springer
This study was conducted to evaluate the effects of Spirulina platensis in Nile tilapia diets on
growth performance, blood hematological and biochemical parameters, immunological …

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

M Zmudzinski, W Rut, K Olech, J Granda, M Giurg… - Scientific reports, 2023 - nature.com
Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against
COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) …

Redox regulation and metabolic dependency of Zika virus replication: Inhibition by Nrf2-antioxidant response and NAD (H) antimetabolites

BR Sahoo, AA Crook, A Pattnaik… - Journal of …, 2023 - Am Soc Microbiol
Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …

Ebselen, a new candidate therapeutic against SARS-CoV-2

CV Haritha, K Sharun, B Jose - International Journal of Surgery, 2020 - journals.lww.com
We read with great interest the recently published article by Abbasi-Oshaghi et al. that
discussed the potential of repurposing FDA-approved drugs and other therapeutic strategies …

Advances in the computational landscape for repurposed drugs against COVID-19

I Aronskyy, Y Masoudi-Sobhanzadeh, A Cappuccio… - Drug Discovery …, 2021 - Elsevier
The COVID-19 pandemic has caused millions of deaths and massive societal distress
worldwide. Therapeutic solutions are urgently needed, but de novo drug development …

Zika virus pathogenesis and current therapeutic advances

C Mwaliko, R Nyaruaba, L Zhao, E Atoni… - … and Global Health, 2021 - Taylor & Francis
Zika virus (ZIKV) is an emerging arthropod-borne flavivirus that, upon infection, results in
teratogenic effects and neurological disorders. ZIKV infections pose serious global public …

Mechanisms of ebselen as a therapeutic and its pharmacology applications

J Wang, P Wang, C Dong, Y Zhao, J Zhou… - Future medicinal …, 2020 - Taylor & Francis
Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …

Reactive oxygen species as potential antiviral targets

WJ Sander, C Fourie, S Sabiu… - Reviews in Medical …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of cellular metabolism and can be either
beneficial, at low levels, or deleterious, at high levels, to the cell. It is known that several viral …