In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Polycomb group (PcG) proteins are important for maintaining the silenced state of homeotic
genes. Biochemical and genetic studies in Drosophila and mammalian cells indicate that …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through
many cycles of cell division. Here, we provide evidence for the sequential binding of PcG …

In the last few years, the discovery of lysine and arginine methylation in histones and other
proteins and the enzymes that carry out these posttranslational modifications has added a …

The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein
BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia …

Polycomb group (PcG) proteins are conserved regulatory proteins that repress transcription
of particular target genes in animals and plants. Studies over the past decade have …

Methylation marks on the lysine residues of histone proteins are thought to contribute to
epigenetic phenomena in part because of their apparent irreversibility. Will this view change …

The epigenetic maintenance of gene expression patterns is essential for developing and
maintaining the diverse types of cell that cooperate to form the larger organism. Recent data …