Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …

The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

Common variable immunodeficiency (CVID), the most prevalent symptomatic primary
immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody …

Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating
chronic disease that lacks known pathogenesis, distinctive diagnostic criteria, and effective …

The tremendous heterogeneity of the human population presents a major obstacle in
understanding how autoimmune diseases like multiple sclerosis (MS) contribute to …

Background Several studies have reported an association between male infertility and
aberrant sperm DNA methylation patterns, in particular in imprinted genes. In a recent …

In 1984, Hrubec and Robinette published what was arguably the first review of the role of
twins in medical research. The authors acknowledged a growing distinction between two …

DNA methylation is an epigenetic modification with wide-ranging consequences across the
life of an organism. This modification can be stable, persisting through development despite …

From the perspective of precision medicine, the challenge for the future is to improve the
accuracy of diagnosis, prognosis, and prediction of therapeutic responses through the …