Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
JM Schaepe, T Fries, BR Doughty, OJ Crocker… - bioRxiv, 2025 - biorxiv.org
The molecular details governing transcription factor (TF) binding and the formation of
accessible chromatin are not yet quantitatively understood-including how sequence context …
accessible chromatin are not yet quantitatively understood-including how sequence context …
Short activation domains control chromatin association of transcription factors
Transcription factors regulate gene expression with DNA-binding domains (DBDs) and
activation domains. It is generally assumed that DBDs are solely responsible for interacting …
activation domains. It is generally assumed that DBDs are solely responsible for interacting …
Coupling CRISPR Scanning with Targeted Chromatin Accessibility Profiling using a Double-Stranded DNA Deaminase
Genome editing enables sequence-function profiling of endogenous cis-regulatory
elements, driving understanding of their mechanisms and the development of gene …
elements, driving understanding of their mechanisms and the development of gene …