Modulation of cellular processes by histone and non-histone protein acetylation

M Shvedunova, A Akhtar - Nature reviews Molecular cell biology, 2022 - nature.com
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ …

Y Ilan - Molecular and Cellular Biochemistry, 2023 - Springer
Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …

Phase separation of EB1 guides microtubule plus-end dynamics

X Song, F Yang, T Yang, Y Wang, M Ding, L Li… - Nature Cell …, 2023 - nature.com
In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …

Phase separation drives decision making in cell division

X Liu, X Liu, H Wang, Z Dou, K Ruan, DL Hill… - Journal of Biological …, 2020 - ASBMB
Liquid–liquid phase separation (LLPS) of biomolecules drives the formation of subcellular
compartments with distinct physicochemical properties. These compartments, free of lipid …

Regulation of end-binding protein EB1 in the control of microtubule dynamics

A Nehlig, A Molina, S Rodrigues-Ferreira… - Cellular and Molecular …, 2017 - Springer
The regulation of microtubule dynamics is critical to ensure essential cell functions, such as
proper segregation of chromosomes during mitosis or cell polarity and migration. End …

Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy

E Forkosh, A Kenig, Y Ilan - Pharmacology Research & …, 2020 - Wiley Online Library
Microtubules (MTs) are highly dynamic polymers that constitute the cellular cytoskeleton and
play a role in multiple cellular functions. Variability characterizes biological systems and is …

Evolving therapeutic strategies to exploit chromosome instability in cancer

LL Thompson, LMP Jeusset, CC Lepage, KJ McManus - Cancers, 2017 - mdpi.com
Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …

Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury

J Huang, D Wan, J Li, H Chen, K Huang, L Zheng - Epigenetics, 2015 - Taylor & Francis
Kidney diseases, including chronic kidney disease (CKD) and acute kidney injury (AKI), are
associated with inflammation. The mechanism that regulates inflammation in these renal …

[HTML][HTML] ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct

G Yayli, A Bernardini, PKM Sanchez, E Scheer… - Cell reports, 2023 - cell.com
To understand the function of multisubunit complexes, it is of key importance to uncover the
precise mechanisms that guide their assembly. Nascent proteins can find and bind their …

Cell death by entosis: triggers, molecular mechanisms and clinical significance

M Kianfar, A Balcerak, M Chmielarczyk… - International Journal of …, 2022 - mdpi.com
Entosis—a homotypic insertion of one cell into another, resulting in a death of the invading
cell—has been described in many reports, but crucial aspects of its molecular mechanisms …