Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

YM Jacobo-Delgado, A Rodríguez-Carlos… - Frontiers in …, 2023 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide
and causes more than 1.5 million deaths annually. To make matters worse, the drug …

Defensins in innate immunity

L Hazlett, M Wu - Cell and tissue research, 2011 - Springer
The innate immune system is the first line of defense against many common
microorganisms, which can initiate adaptive immune responses to provide increased …

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

D Bouskra, C Brézillon, M Bérard, C Werts, R Varona… - Nature, 2008 - nature.com
Intestinal homeostasis is critical for efficient energy extraction from food and protection from
pathogens. Its disruption can lead to an array of severe illnesses with major impacts on …

A replication clock for Mycobacterium tuberculosis

WP Gill, NS Harik, MR Whiddon, RP Liao, JE Mittler… - Nature medicine, 2009 - nature.com
Few tools exist to assess replication of chronic pathogens during infection. This has been a
considerable barrier to understanding latent tuberculosis, and efforts to develop new …

Expression of Cathelicidin LL-37 during Mycobacterium tuberculosis Infection in Human Alveolar Macrophages, Monocytes, Neutrophils, and Epithelial Cells

B Rivas-Santiago, R Hernandez-Pando… - Infection and …, 2008 - Am Soc Microbiol
The innate immune response in human tuberculosis is not completely understood. To
improve our knowledge regarding the role of cathelicidin hCAP-18/LL37 in the innate …

Molecular insights into bacteroid development during Rhizobium–legume symbiosis

AF Haag, MFF Arnold, KK Myka… - FEMS microbiology …, 2013 - academic.oup.com
Rhizobial soil bacteria can form a symbiosis with legumes in which the bacteria fix
atmospheric nitrogen into ammonia that can be utilized by the host. The plant, in turn …

Air pollution particulate matter alters antimycobacterial respiratory epithelium innate immunity

CE Rivas-Santiago, S Sarkar, P Cantarella IV… - Infection and …, 2015 - Am Soc Microbiol
Inhalation exposure to indoor air pollutants and cigarette smoke increases the risk of
developing tuberculosis (TB). Whether exposure to ambient air pollution particulate matter …

Association between ambient air pollution and tuberculosis risk: A systematic review and meta-analysis

K Xiang, Z Xu, YQ Hu, YS He, YL Dan, Q Wu, XH Fang… - Chemosphere, 2021 - Elsevier
There is a growing body of evidence suggesting an association between air pollution
exposure and tuberculosis (TB) incidence, but no meta-analysis has assembled all evidence …

LL-37 immunomodulatory activity during Mycobacterium tuberculosis infection in macrophages

F Torres-Juarez, A Cardenas-Vargas… - Infection and …, 2015 - Am Soc Microbiol
Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility
to this disease depends to a great extent on the innate immune response against …

The role of cathelicidin and defensins in pulmonary inflammatory diseases

C Herr, R Shaykhiev, R Bals - Expert opinion on biological therapy, 2007 - Taylor & Francis
Antimicrobial peptides (AMPs) protect the epithelia of mucosal organs like the respiratory or
the gastrointestinal tract from invading microorganisms. As an integral part of the innate …