What determines large-scale anatomy? DNA does not directly specify geometrical
arrangements of tissues and organs, and a process of encoding and decoding for …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

Diffusion in the plasma membrane of living cells is often found to display anomalous
dynamics. However, the mechanism underlying this diffusion pattern remains highly …

The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …

In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

Monitoring the behavior of single molecules in living cells is a powerful approach to
investigate the details of cellular processes. Owing to their optical, chemical and …

Kv2. 1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane:
One population is freely diffusive and regulates electrical activity via voltage-dependent K+ …

Significant progress in the molecular investigation of endogenous bioelectric signals during
pattern formation in growing tissues has been enabled by recently developed techniques …

The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food
intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine …

To expand the toolbox of imaging in living cells, we have engineered a single-chain variable
fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting …