Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

Extracellular signals regulate protein translation in many cell functions. A key advantage of
control at the translational level is the opportunity to regulate protein synthesis within specific …

The name netrin is derived from the Sanskrit Netr, meaning'guide'. Netrins are a family of
extracellular proteins that direct cell and axon migration during embryogenesis. Three …

Summary DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental
functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on …

Adolescent idiopathic scoliosis (AIS) is an unexplained and common spinal deformity seen
in otherwise healthy children. Its pathophysiology is poorly understood despite intensive …