Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Parkinson disease (PD) is the second most common neurodegenerative movement
disorder. Pharmacological animal models are invaluable tools to study the pathological …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric oxide, NO) are
well recognised for playing a dual role as both deleterious and beneficial species. ROS and …

The neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD),
are age-related disorders characterized by the deposition of abnormal forms of specific …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

The pathogenic mechanisms that underlie Parkinson's disease remain unknown. Here, we
review evidence from both sporadic and genetic forms of Parkinson's disease that implicate …

Parkinson's disease is the second most common neurodegenerative disorder and is
characterized by the degeneration of dopaminergic neurons in the substantia nigra …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Parkinson disease (PD) is associated with progressive loss of dopaminergic neurons in the
substantia nigra, as well as with more-widespread neuronal changes that cause complex …