Locomotion is a complex motor task executed by spinal neurons. Given the diversity of
spinal cord neurons, linking neuronal cell type to function is a challenge. Molecular …

Spinal cord injury (SCI) often results in life-long sensorimotor impairment. Spontaneous
recovery from SCI is limited, as supraspinal fibers cannot spontaneously regenerate to form …

Propriospinal interneurons (INs) communicate information over short and long distances
within the spinal cord. They act to coordinate different parts of the body by linking motor …

Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …

After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating
condition involving involuntary movements, co-contraction of antagonistic muscles, and …

Spinal neural circuits that execute movement are composed of cardinal classes of neurons
that emerged from distinct progenitor lineages. Each cardinal class contains multiple …

Movement and posture depend on sensory feedback that is regulated by specialized
GABAergic neurons (GAD2+) that form axo-axonic contacts onto myelinated proprioceptive …

Traumatic spinal cord injury (SCI) is a leading cause of permanent neurologic disabilities in
young adults. Functional impairments after SCI are substantially attributed to the progressive …

Transcutaneous spinal cord or transspinal stimulation over the thoracolumbar enlargement,
the spinal location of motoneurons innervating leg muscles, modulates neural circuits …

Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for
spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem …