Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European …

D Herrera, M Sanz, L Shapira, C Brotons… - Journal of clinical …, 2023 - Wiley Online Library
Aim To explore the implications for dentists and family doctors of the association between
periodontal and systemic diseases and the role of dentists and family doctors in managing …

Periodontitis and cardiovascular diseases: Consensus report

M Sanz, A Marco del Castillo, S Jepsen… - Journal of clinical …, 2020 - Wiley Online Library
Abstract Background In Europe cardiovascular disease (CVD) is responsible for 3.9 million
deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to …

A genomic mutational constraint map using variation in 76,156 human genomes

S Chen, LC Francioli, JK Goodrich, RL Collins, M Kanai… - Nature, 2024 - nature.com
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders,,–, but …

A genome-wide mutational constraint map quantified from variation in 76,156 human genomes

S Chen, LC Francioli, JK Goodrich, RL Collins, M Kanai… - BioRxiv, 2022 - biorxiv.org
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders, but …

Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier

LM Silva, AD Doyle, T Greenwell-Wild, N Dutzan… - Science, 2021 - science.org
INTRODUCTION Mucosal barrier sites are continuously exposed to diverse environmental
stimuli, and the fine-tuning of mucosal tissue–specific immune responses is key to …

The role of inflammation and genetics in periodontal disease

BG Loos, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …

The relationship of oral health with general health and NCDs: a brief review

C Dörfer, C Benz, J Aida… - International dental …, 2017 - Wiley Online Library
Oral health is closely related to systemic health. Periodontitis, a chronic inflammatory
disease which is highly prevalent worldwide, interacts with a variety of noncommunicable …

Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis

K Jepsen, S Jepsen - Periodontology 2000, 2016 - Wiley Online Library
This review gives an update of the current scientific evidence on the efficacy of the
adjunctive use of systemic and local antibiotics/antimicrobials in the treatment of …

Classification and diagnosis of aggressive periodontitis

DH Fine, AG Patil, BG Loos - Journal of clinical periodontology, 2018 - Wiley Online Library
Objective Since the initial description of aggressive periodontitis (AgP) in the early 1900s,
classification of this disease has been in flux. The goal of this manuscript is to review the …

Periodontal diseases and association with atherosclerotic disease

D Herrera, A Molina, K Buhlin, B Klinge - Periodontology 2000, 2020 - Wiley Online Library
Cardiovascular diseases still account for the majority of deaths worldwide, although
significant improvements in survival, after being affected by cardiovascular disease, have …