Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Boron–nitrogen heteroarenes hold great promise for practical application in many areas of
chemistry. Enduring interest in realizing this potential has in turn driven perennial innovation …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the
development of different tumor types. Despite the remarkable clinical activity of crizotinib …

Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK)
family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously …

Plasma protein binding of drugs is a well-recognised phenomena, but it is only recently that
the implications for drug action in vivo have been fully appreciated. Plasma proteins, by …

Identification of antitumor activity of pyrazole oxime ethers - ScienceDirect Skip to main
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Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

A halogen bond is a noncovalent bond between a halogen atom (X) and a Lewis base (Y).
This type of bond is attributed to the anisotropic distribution of the charge density on the …

Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …