Heat shock protein (Hsp) 90 is an ATP-dependent molecular chaperone that is exploited by
malignant cells to support activated oncoproteins, including many cancer-associated …

The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is
the main cause of cancer-related death in women worldwide. One of the most significant …

HER2 (human epidermal growth factor receptor 2) receptor is a membrane tyrosine kinase
and when activated affects cell proliferation and survival. The HER2 oncogene is located on …

Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is
overexpressed in 20–30% of breast cancers and is associated with poor prognosis and …

Background: Trastuzumab resistance hampers its well-known efficacy to control HER2-
positive breast cancer. The involvement of PI3K/Akt pathway in this mechanism is still not …

The clinical utility of a human epidermal growth factor receptor 2 (HER2)–targeting Affibody
molecule for detection and characterization of HER2-positive lesions was investigated in …

In vivo delivery of siRNAs designed to inhibit genes important in cancer and other diseases
continues to be an important biomedical goal. A new nanoparticle construct that is …

Nanotechnology, along with related concepts such as nanomaterials, nanostructures and
nanoparticles, has become a priority area for scientific research and technological …

Chemoresistance is one of the major hurdles to overcome for the successful treatment of
breast cancer. At present, there are several mechanisms proposed to explain drug …

Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …