1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …

Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

The development of catalytic systems capable of oxygenating unactivated C–H bonds with
excellent site-selectivity and functional group tolerance under mild conditions remains a …

Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …

Controlling remote selectivity and delivering novel functionalities at distal positions in arenes
are an important endeavor in contemporary organic synthesis. In this vein, template …

1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing
and facilitating C–H activation/functionalizations. The hydrogen bond donating ability of this …

Arenes containing conformationally flexible long alkyl chains have been successfully
functionalized at the meta‐position. Good to excellent meta selectivity is achieved for …

An easily removable pyrimidine‐based auxiliary has been employed for the remote meta‐
C− H cyanation of arenes. The scope of this Pd‐catalyzed cyanation reaction using copper …

Conspectus Selective and efficient functionalization of ubiquitous C–H bonds is the Holy
Grail of organic synthesis. Most advances in this area rely on employment of strongly or …