The array of whiskers on the snout provides rodents with tactile sensory information relating
to the size, shape and texture of objects in their immediate environment. Rodents can use …

A central objective in deciphering the nervous system in health and disease is to define the
connections of neurons. The propensity of neurotropic viruses to spread among synaptically …

Synaptic plasticity in the autoassociative network of recurrent connections among
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …

Fragile X syndrome (FXS), the most common inherited form of intellectual disability disorder
and a frequent cause of autism spectrum disorder (ASD), is characterized by a high …

Autism spectrum disorders (ASD) are a set of complex neurodevelopmental disorders for
which there is currently no targeted therapeutic approach. It is thought that alterations of …

Early Alzheimer's disease (AD) affects the brain non-uniformly, causing hippocampal
memory deficits long before wide-spread brain degeneration becomes evident. Here we …

Here we describe “Supernova” series of vector systems that enable single-cell labeling and
labeled cell-specific gene manipulation, when introduced by in utero electroporation (IUE) or …

Neuroinvasive viral infections invade the nervous system, often eliciting serious disease and
death. Members of four viral families are both neuroinvasive and capable of transmitting …

General anesthetics induce loss of consciousness, a global change in behavior. However, a
corresponding global change in activity in the context of defined cortical cell types has not …

Adeno-associated viruses (AAVs) have become highly promising tools for research and
clinical applications in the central nervous system (CNS). However, specific delivery of …