The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Calcium (Ca2+) and Magnesium (Mg2+) reabsorption along the renal tubule is dependent
on distinct trans-and paracellular pathways. Our understanding of the molecular machinery …

Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …

Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial
cells. In the mammalian kidney, every tubular segment express a specific set of claudins that …

Magnesium (Mg2+) is indispensable for several vital functions, such as neurotransmission,
cardiac conductance, blood glucose, blood pressure regulation, and proper function of more …

Magnesium is a divalent cation that fills essential roles as regulator and cofactor in a variety
of biological pathways, and maintenance of magnesium balance is vital to human health …

Understanding mechanisms of hepatocellular damage may lead to new treatments for liver
disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) …

Mg2+ is essential for many cellular and physiological processes, including muscle
contraction, neuronal activity, and metabolism. Consequently, the blood Mg2+ concentration …

Variations in the claudin-14 (CLDN14) gene have been linked to increased risk of
hypercalciuria and kidney stone formation. However, the exact cellular localization of …