Viral tools for neuroscience
AR Nectow, EJ Nestler - Nature Reviews Neuroscience, 2020 - nature.com
Recombinant viruses are the workhorse of modern neuroscience. Whether one would like to
understand a neuron's morphology, natural activity patterns, molecular composition …
understand a neuron's morphology, natural activity patterns, molecular composition …
The alphaviruses: gene expression, replication, and evolution
JH Strauss, EG Strauss - Microbiological reviews, 1994 - Am Soc Microbiol
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …
An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …
Replication and single-cycle delivery of SARS-CoV-2 replicons
Molecular virology tools are critical for basic studies of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
High-throughput mapping of single-neuron projections by sequencing of barcoded RNA
Neurons transmit information to distant brain regions via long-range axonal projections. In
the mouse, area-to-area connections have only been systematically mapped using bulk …
the mouse, area-to-area connections have only been systematically mapped using bulk …
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
EH Schroeter, JA Kisslinger, R Kopan - Nature, 1998 - nature.com
Notch proteins are ligand-activated transmembrane receptors involved in cell-fate selection
throughout development,,. No known enzymatic activity is contained within Notch and the …
throughout development,,. No known enzymatic activity is contained within Notch and the …
Advances in the design and delivery of RNA vaccines for infectious diseases
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
Replicon-helper systems from attenuated venezuelan equine encephalitis virus: Expression of heterologous genesin vitroand immunization against heterologous …
P Pushko, M Parker, GV Ludwig, NL Davis… - Virology, 1997 - Elsevier
A replicon vaccine vector system was developed from an attenuated strain of Venezuelan
equine encephalitis virus (VEE). The replicon RNA consists of thecis-acting 5′ and 3 …
equine encephalitis virus (VEE). The replicon RNA consists of thecis-acting 5′ and 3 …
Dicer-2-dependent generation of viral DNA from defective genomes of RNA viruses modulates antiviral immunity in insects
EZ Poirier, B Goic, L Tomé-Poderti, L Frangeul… - Cell host & …, 2018 - cell.com
The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are
amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature …
amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature …
Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence
KA Tsetsarkin, SC Weaver - PLoS pathogens, 2011 - journals.plos.org
The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus
mosquito, is a major factor contributing to its ongoing re-emergence in a series of large …
mosquito, is a major factor contributing to its ongoing re-emergence in a series of large …