Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

RF Mapanga, MF Essop - American Journal of Physiology …, 2016 - journals.physiology.org
The incidence of cardiovascular complications associated with hyperglycemia is a growing
global health problem. This review discusses the link between hyperglycemia and …

Improvement strategies, cost effective production, and potential applications of fungal glucose oxidase (GOD): current updates

MK Dubey, A Zehra, M Aamir, M Meena… - Frontiers in …, 2017 - frontiersin.org
Fungal glucose oxidase (GOD) is widely employed in the different sectors of food industries
for use in baking products, dry egg powder, beverages, and gluconic acid production. GOD …

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of …

B Szczesny, K Módis, K Yanagi, C Coletta… - Nitric oxide, 2014 - Elsevier
The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases

X Wang, X Ye, R Liu, HL Chen, H Bai, X Liang… - Chemico-biological …, 2010 - Elsevier
Oleanolic acid (OA) is a natural triterpenoid, which has been used in Chinese medicine for
the treatment of liver disorders for many years. Its pharmacological activities have been the …

Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway

Y Zhang, KA Ahmad, FU Khan, S Yan, AU Ihsan… - Chemico-Biological …, 2019 - Elsevier
Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, the
incidence of cardiotoxicity compromises its therapeutic index. Oxidative stress and apoptosis …

[HTML][HTML] IL-10 dysregulation underlies chemokine insufficiency, delayed macrophage response, and impaired healing in diabetic wounds

R Roy, J Zayas, MF Mohamed, A Aboonabi… - Journal of Investigative …, 2022 - Elsevier
Persistent inflammation is a major contributor to healing impairment in diabetic chronic
wounds. Paradoxically, diabetic wound environment during the acute phase of healing is …

N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes

T Wang, X Mao, H Li, S Qiao, A Xu, J Wang… - Free Radical Biology …, 2013 - Elsevier
N-Acetylcysteine (NAC) and allopurinol (ALP) synergistically reduce myocardial ischemia
reperfusion (MI/R) injury in diabetes. However, the mechanism is unclear. We postulated …

Postoperative atrial fibrillation

C Chelazzi, G Villa… - International Scholarly …, 2011 - Wiley Online Library
Postoperative atrial fibrillation (POAF) is common among surgical patients and associated
with a worse outcome. Pathophysiology of POAF is not fully disclosed, and several …

N‐acetylcysteine inhibits hyperglycemia‐induced oxidative stress and apoptosis markers in diabetic neuropathy

SS Kamboj, RK Vasishta… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 112, 77–91. Abstract Several studies have indicated the involvement
of oxidative stress in the development of diabetic neuropathy. In the present study, we have …

Oleanolic acid arrests cell cycle and induces apoptosis via ROS‐mediated mitochondrial depolarization and lysosomal membrane permeabilization in human …

J Wei, M Liu, H Liu, H Wang, F Wang… - Journal of Applied …, 2013 - Wiley Online Library
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits potential anti‐tumor activity against
many tumor cell lines. This study aims to examine the anti‐tumor activity of OA on pancreatic …