Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives

M Asif - International journal of medicinal chemistry, 2014 - Wiley Online Library
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge
consideration owing to their expanded applications in the field of pharmaceutical chemistry …

An overview of triazoloquinazolines: Pharmacological significance and recent developments

HA Abuelizz, R Al-Salahi - Bioorganic Chemistry, 2021 - Elsevier
Nitrogen heterocyclic rings have participated to constitute most of the drugs and several
pharmacologically related compounds. The existence of such hetero atoms/groups in …

Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors

MS Alesawy, AA Al‐Karmalawy… - Archiv Der …, 2021 - Wiley Online Library
Abstract A new series of 1, 2, 4‐triazolo [4, 3‐c] quinazoline derivatives was designed and
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …

Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines

C Balakumar, P Lamba, DP Kishore… - European journal of …, 2010 - Elsevier
A series of novel 8/10-trifluoromethyl-substituted-imidazo [1, 2-c] quinazolines have been
synthesized and evaluated in vivo (rat paw edema) for their anti-inflammatory activity and in …

Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors

WA Ewes, MA Elmorsy, SM El-Messery… - Bioorganic & medicinal …, 2020 - Elsevier
Abstract New series of triazolo [4, 3-c] quinazolines were designed, synthesized and their
structures were elucidated using different spectroscopic techniques. They were evaluated …

Synthesis and anticancer activity of 2-(alkyl-, alkaryl-, aryl-, hetaryl-)-[1, 2, 4] triazolo [1, 5-c] quinazolines

SI Kovalenko, LM Antypenko, AK Bilyi… - Scientia …, 2012 - pmc.ncbi.nlm.nih.gov
The combinatorial library of novel potential anticancer agents, namely, 2-(alkyl-, alkaryl-, aryl-
, hetaryl-)[1, 2, 4] triazolo [1, 5-c] quinazolines, was synthesized by the heterocyclization of …

Novel 3, 3a, 4, 5, 6, 7‐hexahydroindazole and arylthiazolylpyrazoline derivatives as anti‐inflammatory agents

MNA Nasr, SA Said - Archiv der Pharmazie: An International …, 2003 - Wiley Online Library
A novel series of 7‐benzylidene‐3, 3a, 4, 5, 6, 7‐hexahydro‐3‐phenyl‐2H‐indazole
substituted at the 2‐position were synthesized. The reaction of 2, 6‐bis …

Directed search of anti-inflammatory agents among (3H-quinazoline-4-ylidene) hydrazides of N-protected amino acids and their heterocyclization products

Y Martynenko, O Antypenko… - Anti-Inflammatory & …, 2020 - ingentaconnect.com
Background:(Quinazoline-4-ylidene) hydrazides are valued intermediates in modern
organic chemistry, as they are commonly used for the synthesis of substituted [1, 2, 4] …

Synthesis and Antiinflammatory Screening of Some Quinazoline and Quinazolyl‐4‐oxoquinazoline Derivatives

MM Gineinah, MA El‐Sherbeny… - … der Pharmazie: An …, 2002 - Wiley Online Library
Synthesis of some new derivatives of 2‐aryl‐4‐oxo‐1‐(4‐quinazolyl) quinazolines is
described. Methyl N‐(4‐quinazolyl) anthranilate was allowed to react with phenyl iso (thio) …

Synthesis and evaluation of some novel quinazolinone derivatives as diuretic agents

AR Maarouf, ER El‐Bendary… - Archiv der Pharmazie: An …, 2004 - Wiley Online Library
A new series of quinazolin‐4 (3H)‐one derivatives containing either a thiazole or a 1, 3, 4‐
thiadiazole moiety were prepared in order to study the effect of such a heterocyclic …