Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent
pathway for telomere maintenance that is active in a significant subset of human cancers …

Unlimited cellular proliferation depends on counteracting the telomere attrition that
accompanies DNA replication. In human cancers this usually occurs through upregulation of …

Fifteen per cent of cancers maintain telomere length independently of telomerase by the
homologous recombination (HR)-associated alternative lengthening of telomeres (ALT) …

Abstract Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-
based mechanism elongating telomeres in a subset of human cancer cells. While the notion …

Structure-specific endonucleases mediate cleavage of DNA structures formed during repair
of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 …

To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to
telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Recombination-dependent DNA replication, often called break-induced replication (BIR),
was initially invoked to explain recombination events in bacteriophage but it has recently …