This review provides an update of the genetic content, phylogeny and evolution of the family
Adenoviridae. An appraisal of the condition of adenovirus genomics highlights the need to …

▪ Abstract Broadly defined, the concept of gene therapy involves the transfer of genetic
material into a cell, tissue, or whole organ, with the goal of curing a disease or at least …

Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the
presence of coxsackievirus-adenovirus receptors (CAR) and αv integrins on cells. The …

A key factor in the success of gene therapy is the development of gene delivery systems that
are capable of efficient gene transfer in a broad variety of tissues, without causing any …

In the central nervous system (CNS), there are innate obstacles to the modification of
neurons: their relative low abundance versus glia and oligodendrocytes, the inaccessibility …

Recent, rapid advances in deep generative models for protein design have focused on small
proteins with lots of data. Such models perform poorly on large proteins with limited natural …

One of the objectives in adenovirus (Ad) vector development is to target gene delivery to
specific cell types. Major attention has been given to modification of the Ad fiber knob, which …

Replication-defective vectors based on human adenovirus serotypes 2 and 5 (Ad2 and Ad5)
possess a number of attributes which favor their use as gene delivery vehicles in gene …

Cancer gene therapy approaches will derive considerable benefit from adenovirus (Ad)
vectors capable of self-directed localization to neoplastic disease or immunomodulatory …