Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …

The thymus plays a key role in adaptive immunity by generating a diverse population of T
cells that defend the body against pathogens. Various factors from disease and toxic insults …

Relative potency factors (RPFs) for per-and polyfluoroalkyl substances (PFAS) have
previously been derived based on liver effects in rodents for the purpose of performing …

The dynamic roles of T cells in the immune system to recognize and destroy the infected or
mutated cells render T cell therapy a prospective treatment for a variety of diseases …

The thymus is a primary lymphoid organ essential for the induction of central immune
tolerance. Maturing T cells undergo several steps of expansion and selection mediated by …

Tissue loss and end-stage organ failure are serious health problems across the world.
Natural and synthetic polymer scaffold material based artificial organs play an important role …

We engineered an in vitro model of bioartificial 3D bone organoid consistent with an
anatomical and vascular microenvironment common to mammalian flat and short bones. To …

Recent technological advances have transformed our understanding of the human thymus.
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …

The thymus plays a pivotal role in generating a highly-diverse repertoire of T lymphocytes
while preventing autoimmunity. Thymus seeding progenitors (TSPs) are a heterogeneous …

We recently designed an innovative scaffold-bioreactor unit for the bioengineering of a three-
dimensional (3D) bioartificial human thyroid gland or its miniaturized replica as a part of a …