Machine-Learning Classification of Bacteria Using Two-Dimensional Tandem Mass Spectrometry

LE Gonzalez, DT Snyder, H Casey, Y Hu… - Analytical …, 2023 - ACS Publications
Biothreat detection has continued to gain attention. Samples suspected to fall into any of the
CDC's biothreat categories require identification by processes that require specialized …

Top-down proteoform analysis by 2D MS with quadrupolar detection

M Polák, M Palasser, A Kádek, D Kavan… - Analytical …, 2023 - ACS Publications
Two-dimensional mass spectrometry (2D MS) is a multiplexed tandem mass spectrometry
method that does not rely on ion isolation to correlate the precursor and fragment ions. On a …

Two-Dimensional Mass Spectrometry Analysis of IgG1 Antibodies

J Paris, TE Morgan, BP Marzullo… - Journal of the …, 2021 - ACS Publications
Two-dimensional mass spectrometry (2DMS) is a new, and theoretically ideal, data-
independent analysis tool, which allows the characterization of a complex mixture and was …

Characterization across a dispersity: polymer mass spectrometry in the second dimension

TE Morgan, CA Wootton, B Marzullo… - Journal of the …, 2021 - ACS Publications
Due to the natural dispersity that is present in synthetic polymers, an added complexity is
always present in the analysis of polymeric species. Tandem mass spectrometry analysis …

Ultra-Accurate Correlation between Precursor and Fragment Ions in Two-Dimensional Mass Spectrometry: Acetylated vs Trimethylated Histone Peptides

M Palasser, SV Heel, MA Delsuc… - Journal of the …, 2023 - ACS Publications
Two-dimensional mass spectrometry (2D MS) is a method for tandem mass spectrometry in
which precursor and fragment ions are correlated by manipulating ion radii rather than by …

Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of N-Linked Glycopeptides

RJ Bell, DS Hage, ED Dodds - Journal of the American Society for …, 2024 - ACS Publications
Glycosylation is a common modification across living organisms and plays a central role in
understanding biological systems and disease. Our ability to probe the gylcome has grown …

Fellgett Revisited: On the Nature of Noise in Two-Dimensional Mass Spectrometry

C Littlejohn, M Li, PY Lam, MP Barrow… - Journal of the …, 2024 - ACS Publications
Two-dimensional mass spectrometry (2DMS) is a truly data-independent acquisition
technique used in the analysis of complex mixtures; however, the nature of the noise within …

Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Matrix-Assisted Laser Desorption Ionization

RJ Bell, DS Hage, ED Dodds - Analytical Chemistry, 2024 - ACS Publications
Two-dimensional Fourier transform ion cyclotron resonance (2D FTICR) mass spectrometry
is a developing form of data-independent acquisition that allows for the simultaneous …

Advancing PROTAC Characterization: Structural Insights through Adducts and Multimodal Tandem-MS Strategies

M Rahman, B Marzullo, SW Holman… - Journal of the …, 2024 - ACS Publications
Proteolysis targeting chimeras (PROTACs) are specialized molecules that bind to a target
protein and a ubiquitin ligase to facilitate protein degradation. Despite their significance …

Two-dimensional partial covariance mass spectrometry for the top–down analysis of intact proteins

T Driver, V Averbukh, LJ Frasinski… - Analytical …, 2021 - ACS Publications
Two-dimensional partial covariance mass spectrometry (2D-PC-MS) exploits the inherent
fluctuations of fragment ion abundances across a series of tandem mass spectra, to identify …