Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

The appearance of modular proteins is a widespread phenomenon during the evolution of
proteins. The combinatorial arrangement of different functional and/or structural domains …

Background A blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite
Plasmodium falciparum could play a role to protect against clinical disease. Antibodies …

With emerging resistance to frontline treatments, it is vital that new drugs are identified to
target Plasmodium falciparum. One of the most critical processes during parasites asexual …

Malaria remains a heavy public health and socioeconomic burden in tropical and
subtropical regions. Increasing resistance against front-line treatments implies that novel …

Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …

Even though several in silico tools are available for prediction of the phosphorylation sites
for mammalian, yeast or plant proteins, currently no software is available for predicting …

There are important challenges when investigating individual post-translational
modifications (PTMs) or protein interaction network and delineating if PTMs or their changes …

The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological
processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a …

Abstract The enzyme Heme O Synthase (HOS) is essential for producing heme A and heme
O, which are critical for defense against reactive oxygen species, drug detoxification, gas …