Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form
one of the main branches of the immune system. As IELs are located at this critical interface …

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise
roles in intestinal inflammation remain unknown. Here we show that activation of mast cells …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

The digestive tract is home to millions of microorganisms and is the main and most important
part of bacterial colonization. On one hand, the abundant bacterial community in intestinal …

An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …

Abstract TCRαβ+ CD4− CD8α+ CD8β− intestinal intraepithelial lymphocytes (CD8αα IELs)
are an abundant population of thymus-derived T cells that protect the gut barrier surface. We …

The word is currently experiencing a coronavirus disease-19 (COVID-19) pandemic caused
by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) …

The moniker lysophospholipid incorporates two broad families of membrane-derived lipids:
the glycerophospholipids and the sphingolipids. 1 Primary representatives of these two arms …

The intestinal epithelium and underlying lamina propria contains large numbers of T cells
that play an important role in maintaining intestinal homeostasis and defense against …