Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Targeted delivery to the diseased cell or tissue is the key to the successful clinical use of
nucleic acid drugs. In particular, delivery of microRNA-140 (miRNA-140, miR-140) into …

Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …

Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis
(OA)“difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated …

OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world.
Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells …

Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

ABSTRACT SOX9 is a pivotal transcription factor in developing and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …