Personalized mRNA vaccines in glioblastoma therapy: from rational design to clinical trials
I Karimi-Sani, Z Molavi, S Naderi, SH Mirmajidi… - Journal of …, 2024 - Springer
Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors,
presenting significant challenges for treatment due to their invasive nature and localization …
presenting significant challenges for treatment due to their invasive nature and localization …
Development of therapeutic-grade small interfering RNAs by chemical engineering
JB Bramsen, J Kjems - Frontiers in genetics, 2012 - frontiersin.org
Recent successes in clinical trials have provided important proof of concept that small
interfering RNAs (siRNAs) indeed constitute a new promising class of therapeutics. Although …
interfering RNAs (siRNAs) indeed constitute a new promising class of therapeutics. Although …
Identification and application of exogenous dsRNA confers plant protection against Sclerotinia sclerotiorum and Botrytis cinerea
Sclerotinia sclerotiorum, the causal agent of white stem rot, is responsible for significant
losses in crop yields around the globe. While our understanding of S. sclerotiorum infection …
losses in crop yields around the globe. While our understanding of S. sclerotiorum infection …
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
[HTML][HTML] A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein …
An outbreak, caused by an RNA virus, SARS-CoV-2 named COVID-19 has become
pandemic with a magnitude which is daunting to all public health institutions in the absence …
pandemic with a magnitude which is daunting to all public health institutions in the absence …
Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
The devastating outbreak of COVID-19 has spread all over the world and has become a
global health concern. There is no specific therapeutics to encounter the COVID-19. Small …
global health concern. There is no specific therapeutics to encounter the COVID-19. Small …
The role of RNA‐binding proteins in mediating adaptive responses in Gram‐positive bacteria
N Christopoulou, S Granneman - The FEBS journal, 2022 - Wiley Online Library
Bacteria are constantly subjected to stressful conditions, such as antibiotic exposure,
nutrient limitation and oxidative stress. For pathogenic bacteria, adapting to the host …
nutrient limitation and oxidative stress. For pathogenic bacteria, adapting to the host …
Enhanced Cas12a multi-gene regulation using a CRISPR array separator
The type VA Cas12a protein can process its CRISPR array, a feature useful for multiplexed
gene editing and regulation. However, CRISPR arrays often exhibit unpredictable …
gene editing and regulation. However, CRISPR arrays often exhibit unpredictable …
Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy
OM Hedaya, KC Venkata Subbaiah, F Jiang… - Nature …, 2023 - nature.com
Translation of upstream open reading frames (uORFs) typically abrogates translation of
main (m) ORFs. The molecular mechanism of uORF regulation in cells is not well …
main (m) ORFs. The molecular mechanism of uORF regulation in cells is not well …
Exploring the challenges of RNAi-based strategies for crop protection
JH Zhao, QY Liu, ZM Xie, HS Guo - Advanced Biotechnology, 2024 - Springer
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a
conserved mechanism for regulating gene expression in eukaryotes. RNAi-based crop …
conserved mechanism for regulating gene expression in eukaryotes. RNAi-based crop …