Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
S Malik, RG Roeder - Nature Reviews Genetics, 2023 - nature.com
Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …
Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
Structural insights into preinitiation complex assembly on core promoters
INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription
The Polycomb system has fundamental roles in regulating gene expression during
mammalian development. However, how it controls transcription to enable gene repression …
mammalian development. However, how it controls transcription to enable gene repression …
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation
P Versluis, TGW Graham, V Eng, J Ebenezer… - Molecular Cell, 2024 - cell.com
Summary RNA polymerase II (RNA Pol II)-mediated transcription is a critical, highly
regulated process aided by protein complexes at distinct steps. Here, to investigate RNA Pol …
regulated process aided by protein complexes at distinct steps. Here, to investigate RNA Pol …
The Mediator kinase module: an interface between cell signaling and transcription
O Luyties, DJ Taatjes - Trends in biochemical sciences, 2022 - cell.com
The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …
Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB
JF Santana, GS Collins, M Parida, DS Luse… - Nucleic acids …, 2022 - academic.oup.com
The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general
transcription factors (GTFs) that are thought to be critical for formation of preinitiation …
transcription factors (GTFs) that are thought to be critical for formation of preinitiation …
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by
phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few …
phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few …