This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …

Marine natural products represent novel and diverse chemotypes that serve as templates for
the discovery and development of therapeutic agents with distinct mechanisms of action …

Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a
key to immune suppressive microenvironment in solid tumors. Many studies have revealed …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through
the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant …

Innovative discovery strategies are essential to address the ongoing opioid epidemic in the
United States. Misuse of prescription and illegal opioids (eg, morphine, heroin) has led to …

Cyanobacteria produce a plethora of compounds with unique chemical structures and
diverse biological activities. Importantly, the increasing availability of cyanobacterial genome …

Amantamides are lipopeptides that act as selective CXC chemokine receptor 7 agonists and
modulate spontaneous calcium oscillations in primary cultured neocortical neurons. We …

Covering 2010–April 2024 There have been tremendous new discoveries and
developments since 2010 in anticancer research based on marine cyanobacteria. Marine …

The secondary metabolites of marine fungi with rich chemical diversity and biological activity
are an important and exciting target for natural product research. This study aimed to …