Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

The discovery, approximately 15 years ago, that cortical GABA ergic interneurons originate
outside the pallium has revolutionized our understanding of the development of the cerebral …

GABAergic interneurons are inhibitory neurons of the nervous system that play a vital role in
neural circuitry and activity. They are so named due to their release of the neurotransmitter …

Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

The emergence of functional neuronal connectivity in the developing cerebral cortex
depends on neuronal migration. This process enables appropriate positioning of neurons …

The orderly development of the nervous system is characterized by phases of cell
proliferation and differentiation, neural migration, axonal outgrowth and synapse formation …

A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …

GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the
embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by …

Tuberous sclerosis complex (TSC) is a genetic disease with severe neurologic and
psychiatric manifestations including epilepsy, developmental delay, and autism. Despite …

Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a
clear minority compared to the vast number of excitatory projection neurons. They are …