Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

Over the last decade, a rich variety of massively parallel assays have revolutionized our
understanding of how biological sequences encode quantitative molecular phenotypes …

A general method to generate biosensors for user-defined molecules could provide
detection tools for a wide range of biological applications. Here, we describe an approach …

Plants sense abscisic acid (ABA) using chemical-induced dimerization (CID) modules,
including the receptor PYR1 and HAB1, a phosphatase inhibited by ligand-activated PYR1 …

Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is
essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de …

Thousands of proteins have been validated genetically as therapeutic targets for human
diseases. However, very few have been successfully targeted, and many are considered …

Metagenomics is unearthing the previously hidden world of soil viruses. Many soil viral
sequences in metagenomes contain putative auxiliary metabolic genes (AMGs) that are not …

A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell
receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic …

Determining the three-dimensional structures of macromolecules is a major goal of
biological research, because of the close relationship between structure and function; …

Deep mutational scanning is a widely used method for multiplex measurement of functional
consequences of protein variants. We developed a new deep mutational scanning statistical …