[HTML][HTML] The evolving story of apolipoprotein L1 nephropathy: the end of the beginning
P Daneshpajouhnejad, JB Kopp, CA Winkler… - Nature Reviews …, 2022 - nature.com
Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …
identified in 2010 and are relatively common among individuals of sub-Saharan African …
[HTML][HTML] The evolving role of diagnostic genomics in kidney transplantation
J Soraru, A Chakera, N Isbel… - Kidney International …, 2022 - Elsevier
Monogenic forms of heritable kidney disease account for a significant proportion of chronic
kidney disease (CKD) across both pediatric and adult patient populations and up to 11% of …
kidney disease (CKD) across both pediatric and adult patient populations and up to 11% of …
[HTML][HTML] Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival
Donor-recipient (DR) mismatches outside of human leukocyte antigens (HLAs) contribute to
kidney allograft loss, but the mechanisms remain unclear, specifically for intronic …
kidney allograft loss, but the mechanisms remain unclear, specifically for intronic …
Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts
F Zanoni, YD Neugut, JE Obayemi, L Liu… - American Journal of …, 2024 - Elsevier
African American (AA) kidney recipients have a higher risk of allograft rejection and failure
compared to non-AAs, but to what extent these outcomes are due to genetic versus …
compared to non-AAs, but to what extent these outcomes are due to genetic versus …
Treatment potential in APOL1-associated nephropathy
DJ Friedman, L Ma, BI Freedman - Current opinion in nephrology …, 2022 - journals.lww.com
APOL1-associated nephropathy includes a group of related phenotypes that are driven by
the same two genetic variants in APOL1. Clinical trials of small molecule inhibitors, ASO …
the same two genetic variants in APOL1. Clinical trials of small molecule inhibitors, ASO …
Association of recipient APOL1 kidney risk alleles with kidney transplant outcomes
Background. Kidney transplant survival in African American recipients is lower compared
with non–African American transplant recipients. APOL1 risk alleles (RA) have been …
with non–African American transplant recipients. APOL1 risk alleles (RA) have been …
[PDF][PDF] Evaluating ApoL1 genetic testing policy options for transplant centers: a Delphi consensus panel project with stakeholders
T McIntosh, H Walsh, K Baldwin, A Iltis… - Clinical Journal of the …, 2024 - journals.lww.com
Background: ApoL1 variants G1 and G2 are associated with a higher risk of kidney disease.
ApoL1 risk variants are predominantly seen in individuals with sub-Saharan African …
ApoL1 risk variants are predominantly seen in individuals with sub-Saharan African …
[HTML][HTML] Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury
M Andrews, T Yoshida, CM Henderson, H Pflaum… - PloS one, 2022 - journals.plos.org
Background Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans
from infection with African trypanosomes, explain a substantial proportion of the excess risk …
from infection with African trypanosomes, explain a substantial proportion of the excess risk …
Time to abolish metrics that sustain systemic racism in kidney allocation
Inequitiesinhealthcarearemagnifiedinkidne…-tation because of the gross imbalance
between the need and supply of donated kidneys. Currently, nearly 90 000 …
between the need and supply of donated kidneys. Currently, nearly 90 000 …
[HTML][HTML] Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms
P Jethwani, A Rao, L Bow, MC Menon - Frontiers in Immunology, 2022 - frontiersin.org
Despite significant improvement in the rates of acute allograft rejection, proportionate
improvements in kidney allograft longevity have not been realized, and are a source of …
improvements in kidney allograft longevity have not been realized, and are a source of …