The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …

The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Inflammasomes are large cytosolic multiprotein complexes that assemble in response to
detection of infection-or stress-associated stimuli and lead to the activation of caspase-1 …

One of the fundamental reactions of the innate immune responses to pathogen infection is
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …

Viral infection triggers host innate immune responses, which primarily include the activation
of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) …

Host organisms utilise a range of genetically encoded cell death programmes in response to
pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Autoinflammatory syndromes cause sterile inflammation in the absence of any signs of
autoimmune responses. Familial cold autoinflammatory syndrome (FCAS) is characterized …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3), is involved in the early stages
of the inflammatory response by sensing cellular damage or distress due to viral or bacterial …