Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …

The valves of the heart are crucial for ensuring that blood flows in one direction from the
heart, through the lungs and back to the rest of the body. Heart valve development is …

Objective: Leaflet thickening, fibrosis, and hardening are early pathological features of
calcific aortic valve disease (CAVD). An inadequate understanding of the resident aortic …

Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in
developed countries and in the ageing population. It is strongly correlated to median age …

Extracellular vesicles (EVs) are important mediators of intercellular communication within
the cardiovascular system, playing essential roles in physiological homeostasis and …

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …

Calcific aortic valve stenosis (CAS), the most prevalent valvular disease worldwide, has
been demonstrated to frequently occur in conjunction with coronary artery disease (CAD) …

Background Preliminary studies indicated that enhanced plasma levels of lipoprotein (a)[lp
(a)] might link with the risk of calcific aortic valve disease (CAVD), but the clinical association …

Calcific aortic valve stenosis (CAVS), the third most prevalent cardiovascular disorder is
known to impose a huge social and economic burden on patients. However, no …