Current and emerging biomarkers of frailty in the elderly

AA Saedi, J Feehan, S Phu, G Duque - Clinical interventions in …, 2019 - Taylor & Francis
The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

Pathogenesis of acquired heterotopic ossification: risk factors, cellular mechanisms, and therapeutic implications

G Cao, S Zhang, Y Wang, S Quan, C Yue, J Yao… - Bone, 2023 - Elsevier
Heterotopic ossification (HO), including hereditary and acquired HO, is the formation of
extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often …

Murine tissue‐resident PDGFRα+ fibro‐adipogenic progenitors spontaneously acquire osteogenic phenotype in an altered inflammatory environment

C Eisner, M Cummings, G Johnston… - Journal of Bone and …, 2020 - academic.oup.com
Acquired heterotopic ossifications (HO) arising as a result of various traumas, including
injury or surgical interventions, often result in pain and loss of motion. Though triggers for …

Pathophysiology and emerging molecular therapeutic targets in heterotopic ossification

F Felix-Ilemhenbhio, GAE Pickering… - International Journal of …, 2022 - mdpi.com
The term heterotopic ossification (HO) describes bone formation in tissues where bone is
normally not present. Musculoskeletal trauma induces signalling events that in turn trigger …

Return to play after treating acute muscle injuries in elite football players with radial extracorporeal shock wave therapy

JPM Morgan, M Hamm, C Schmitz, MH Brem - Journal of Orthopaedic …, 2021 - Springer
Background To compare lay-off times achieved by treating acute muscle injuries in elite
football players with a multimodal therapy approach that includes a specific protocol of …

Circulating Osteoprogenitor Cells Have a Mixed Immune and Mesenchymal Progenitor Function in Humans

J Feehan, M Jacques, D Kondrikov, N Eynon… - Stem Cells, 2023 - academic.oup.com
Background Circulating osteoprogenitors (COP) are a population of cells in the peripheral
circulation that possess functional and phenotypical characteristics of multipotent stromal …

Inflammation in fibrodysplasia ossificans progressiva and other forms of heterotopic ossification

K Matsuo, RD Chavez, E Barruet, EC Hsiao - Current Osteoporosis …, 2019 - Springer
Purpose of review Heterotopic ossification (HO) is associated with inflammation. The goal of
this review is to examine recent findings on the roles of inflammation and the immune …

Circulating osteogenic precursor cells: Building bone from blood

J Feehan, K Nurgali, V Apostolopoulos, A Al Saedi… - …, 2019 - thelancet.com
Circulating osteogenic precursor (COP) cells constitute a recently discovered population of
circulating progenitor cells with the capacity to form not only bone but other mesenchymal …

Biomaterials in heterotopic ossification: Prophylaxis and promotion

X Lou, D Huang, G Li, L Bai, J Su, H Yue - Chemical Engineering Journal, 2024 - Elsevier
Heterotopic ossification (HO) is an abnormal bone formation within non-skeletal tissues,
impairing daily functionality and significantly diminishing patient quality of life. This condition …

Circulating biomarkers for diagnosis and therapeutic monitoring in bone metastasis

MK Song, SI Park, SW Cho - Journal of Bone and Mineral Metabolism, 2023 - Springer
Bone is a frequent site of metastasis for multiple types of solid tumors in organs such as
prostate, breast, lung, etc., accounting for significant morbidities and mortalities of afflicted …