Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …

Focal adhesions are large protein complexes organized at the basal surface of cells, which
physically connect the extracellular matrix to the cytoskeleton and have long been …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

Viral infection converts the normal functions of a cell to optimize viral replication and virion
production. One striking observation of this conversion is the reconfiguration and …

Fascin is an actin-bundling protein involved in filopodia assembly and cancer invasion and
metastasis of multiple epithelial cancer types. Fascin forms stable actin bundles with slow …

This paper introduces the method of live-cell multiple-particle-tracking microrheology
(MPTM), which quantifies the local mechanical properties of living cells by monitoring the …

The mechanical stability and integrity of biological cells is provided by the cytoskeleton, a
semidilute meshwork of biopolymers. Recent research has underscored its role as a …

Current biochemical characterizations of cystic fibrosis (CF) sputum do not address the high
degree of microheterogeneity in the rheological properties of the mucosal matrix and only …

The actin cytoskeleton, a network of protein-polymers, is responsible for the mechanical
stability of cells. This biopolymer network is also crucial for processes that require spatial …