Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …
Structure-based search for new inhibitors of cholinesterases
M Bajda, A Więckowska, M Hebda, N Guzior… - International journal of …, 2013 - mdpi.com
Cholinesterases are important biological targets responsible for regulation of cholinergic
transmission, and their inhibitors are used for the treatment of Alzheimer's disease. To …
transmission, and their inhibitors are used for the treatment of Alzheimer's disease. To …
Acetylcholinesterase inhibitors: a patent review (2008–present)
M Pohanka - Expert opinion on therapeutic patents, 2012 - Taylor & Francis
Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are
present in the body in large amounts. AChE is an important part of the cholinergic nervous …
present in the body in large amounts. AChE is an important part of the cholinergic nervous …
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …
pathophysiologies. Compounds that modulate protein aggregation and interact with …
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease
RS Li, XB Wang, XJ Hu, LY Kong - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
A new series of flavonoid derivatives were designed, synthesized and evaluated as potential
multifunctional AChE inhibitors against Alzheimer's disease. Most of them exhibited potent …
multifunctional AChE inhibitors against Alzheimer's disease. Most of them exhibited potent …
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease
Abstract Development of multitargeted ligands have demonstrated remarkable efficiency as
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …
Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors
H Liu, X Liu, H Fan, J Tang, X Gao, WK Liu - Bioorganic & medicinal …, 2014 - Elsevier
A novel series of chalcone derivatives (4a–8d) were designed, synthesized, and evaluated
for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase …
for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase …
Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors
R Xie, Q Zhao, T Zhang, J Fang, X Mei, J Ning… - Bioorganic & medicinal …, 2013 - Elsevier
The cluster effect is an effective strategy to explore new lead compounds, and has been
successfully applied in rational drug design and screening. A series of novel …
successfully applied in rational drug design and screening. A series of novel …
Tricyclic quinazoline alkaloids: isolation, synthesis, chemical modification, and biological activity
KM Shakhidoyatov, BZ Elmuradov - Chemistry of natural compounds, 2014 - Springer
Tricyclic Quinazoline Alkaloids: Isolation, Synthesis, Chemical Modification, and Biological
Activity | SpringerLink Skip to main content Advertisement SpringerLink Log in Menu Find a …
Activity | SpringerLink Skip to main content Advertisement SpringerLink Log in Menu Find a …