The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Nanoscience and nanotechnology has caused important breakthroughs in different
therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led …

Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers
that enable safe and efficient intracellular delivery. Before the desired site of action is …

Importance of the field: Active targeting of bioactive molecules by physicochemical
association with hyaluronic acid (HA) is an attractive approach in current nanomedicine …

Lipoplexes and polyplexes, electrostatic complexes between a plasmid DNA and cationic
lipids or polymers are chemical systems that are developed for gene delivery. Considerable …

Retinal gene therapy could potentially affect the lives of millions of people suffering from
blinding disorders. Yet, one of the major hurdles remains the delivery of therapeutic nucleic …

Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …

As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …