The Schlafen family: complex roles in different cell types and virus replication

F Liu, P Zhou, Q Wang, M Zhang… - Cell biology …, 2018 - Wiley Online Library
The Schlafen (slfn) gene family members express broadly, but the research has mainly
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …

Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence

O Bustos, S Naik, G Ayers, C Casola… - Gene, 2009 - Elsevier
Genes of the Schlafen family, first discovered in mouse, are expressed in hematopoietic
cells and are involved in immune processes. Previous results showed that they are …

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

L Zhao, EA Glazov, DR Pattabiraman… - Nucleic acids …, 2011 - academic.oup.com
To gain insight into the mechanisms by which the Myb transcription factor controls normal
hematopoiesis and particularly, how it contributes to leukemogenesis, we mapped the …

From mammals to viruses: the Schlafen genes in developmental, proliferative and immune processes

E de la Casa-Esperón - 2011 - degruyter.com
The Schlafen genes have been associated with proliferation control and with several
differentiation processes, as well as with disparate phenotypes such as immune response …

[HTML][HTML] Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells

A Puck, R Aigner, M Modak, P Cejka, D Blaas… - Results in …, 2015 - Elsevier
Schlafen (SLFN/Slfn) family members have been investigated for their involvement in
fundamental cellular processes including growth regulation, differentiation and control of …

Subcellular localization of the Schlafen protein family

B Neumann, L Zhao, K Murphy, TJ Gonda - Biochemical and biophysical …, 2008 - Elsevier
Although the first members of the Schlafen gene family were first described almost 10 years
ago, the precise molecular/biochemical functions of the proteins they encode still remain …

Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication

RK Seong, S Seo, JA Kim, SJ Fletcher, NV Morgan… - Immunobiology, 2017 - Elsevier
Schlafen (SLFN) proteins have been suggested to play important functions in cell
proliferation and immune cell development. In this study, we determined the antiviral …

Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation

RS Pais, N Moreno-Barriuso, I Hernández-Porras… - PloS one, 2013 - journals.plos.org
Background Insulin-like Growth Factor 1 (IGF1) is a multifunctional regulator of somatic
growth and development throughout evolution. IGF1 signaling through IGF type 1 receptor …

Structure–function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination

L Zhao, ET Ng, TL Davidson… - Proceedings of the …, 2014 - National Acad Sciences
The mammalian sex-determining factor SRY comprises a conserved high-mobility group
(HMG) box DNA-binding domain and poorly conserved regions outside the HMG box …

Characterization of Schlafen-3 expression in effector and regulatory T cells

T Condamine, JB Le Luduec… - Journal of leukocyte …, 2010 - academic.oup.com
The study's results suggest that Slfn3 could have a role in T cell differentiation and
activation. Members of the Slfn protein family have been implicated in the regulation of cell …